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September 17, 2025Frontiers in ImmunologyOpen Access

Case Report: Relapsing pleural effusions and coated aorta revealing Erdheim–Chester disease

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Authors

TOT. OuattaraTPThéo PezelGLGwenaël Lorillon

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Overview

Case report reveals pleural effusions and coated aorta in a patient with Erdheim–Chester disease, suggesting non-invasive diagnostic methods.

Key Points

  • Pleural effusions revealed a key clinical manifestation in a patient with Erdheim–Chester disease.
  • Immunohistochemistry showed significant infiltration by histiocytes, aiding the diagnosis of this rare disorder.
  • The presence of a MAP2K1 mutation was identified as a key driver mutation associated with Erdheim–Chester disease.
  • Timely diagnosis is challenging but can benefit from non-invasive genetic testing using plasma cell-free DNA.

Cite This Study

Ouattara et al. (2025) studied this question.

synapsesocial.com/papers/68d46ccf31b076d99fa691b8https://doi.org/10.3389/fimmu.2025.1585541
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Erdheim-Chester disease: unveiling hidden manifestations through two case reports2025
  2. 2Erdheim‑Chester disease of multisystem involvement with delayed diagnosis: A case report and literature review2024 · 2 citations
  3. 3Erdheim-Chester Disease with multisystem involvement: A diagnostic dilemma mimicking autoimmune and inflammatory diseases: Case report and a brief literature review2025
  4. 4Cardiovascular Involvement in Erdheim–Chester Disease Presenting as Pericardial Tamponade: A Case Report and Multimodality Imaging Review2026
  5. 5Erdheim–Chester disease: An elusive diagnosis in a 50‐year‐old Ethiopian man presenting with diffuse sclerotic bone lesion2024 · 1 citations