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September 18, 2025Separation Science Plus

Quality by Design‐Driven Development, Greenness, and Whiteness Assessment of a Robust RP‐HPLC Method for Simultaneous Quantification of Ellagic, Sinapic, and Syringic Acids

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Authors

RKRahul KoliKLE UniversityRKRahul KoliKLE UniversityAMAtith MuppayyanamathKLE University

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Implication

This method simultaneously quantifies ellagic, sinapic, and syringic acids, highlighting its greenness and effectiveness.

Key Points

  • The RP-HPLC method achieves excellent linearity (R2 > 0.999) and sensitivity for simultaneous acid quantification.
  • Optimal conditions were established using a mobile phase of methanol and formic acid, with a flow rate of 1.0 mL/min.
  • Environmental assessment revealed the method's high ecological compatibility, with Eco-Scale score of 77.
  • The integrated analytical strategy combines scientific rigor and green chemistry principles for routine applications.

Cite This Study

Koli et al. (2025) studied this question.

synapsesocial.com/papers/68d46ccf31b076d99fa692a0https://doi.org/10.1002/sscp.70126
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