Novel method demonstrates efficient deprotection of alloc groups in alcohols, indicating broad substrate scope.
A novel protocol for the deprotection of O-allyloxycarbonyl(alloc) group by nickel(II) chloride hexahydrate with sodium borohydride in acetone at 0 ºC to give the corresponding parent alcohols and phenols in high yields was demonstrated. This method had the advantages of mild reaction condition and broad substrate scope. The deprotection had also been validated in gram scale, to establish its appropriateness of this protocol.
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Yuan et al. (2025) studied this question.
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