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September 21, 2025Stem Cell ReportsOpen Access

Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells

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Authors

RWRachel WellingtonXCXiaoyi ChengSDSuman Dutta

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Overview

This analysis identifies key receptor interactions and FGF signaling effects on stem cell differentiation from iPSCs.

Key Points

  • Endothelial-to-hematopoietic transition (EHT) from induced pluripotent stem cells (iPSCs) enhances HSC generation.
  • Decreased FGF signaling during EHT promotes normal hematopoiesis and supports stem cell development.
  • Single-cell mapping reveals critical ligand-receptor interactions that influence iPSC differentiation processes.
  • Chemical inhibition of FGF enhances the development of hematopoietic stem cells in zebrafish and derived from iPSCs.

Cite This Study

Wellington et al. (2025) studied this question.

synapsesocial.com/papers/68d46fd431b076d99fa6a223https://doi.org/10.1016/j.stemcr.2025.102641
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells2024 · 1 citations
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  3. 3Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells2024 · 4 citations
  4. 4Restraint of TGF-β signaling by SMAD7 is necessary for the maturation of hematopoietic stem cells in the mouse embryo2025
  5. 5Mechanistic insights into gene regulation driving normal and malignant hematopoietic development from embryonic and induced pluripotent stem cell differentiation.2026