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This is a Literature Review study.

September 23, 2025Journal of Medical ScienceOpen Access

Therapeutic Targeting of Low-density lipoprotein receptor-related protein-1 (LRP1) gene in Ovarian Cancer: A Comprehensive Review

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This review explores the role of LRP1 in ovarian cancer, highlighting its influence on tumour progression and signalling pathways.

LRP1 promotes ovarian cancer tumour progression through key molecular pathways.
Activation of PI3K/Akt and MAPK/ERK pathways is linked to LRP1's role in cell proliferation.
Inhibiting LRP1 can suppress proliferation and invasion of ovarian cancer cells.
Understanding LRP1's function may lead to new therapeutic strategies for ovarian cancer treatment.

Krishna et al. (2025) studied this question.

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