Pyridinium Bromide Perbromide (PyHBr₃) Promoted One‐Pot Synthesis of Quinoxaline and Aminothiazole Derivatives From Acetophenone

A straightforward, metal‐free synthesis of quinoxaline and aminothiazole derivatives from acetophenone is reported. The reaction was found to be promoted by pyridinium bromide perbromide, a little‐explored brominating reagent. A wide variety of substituted quinoxaline and aminothiazole derivatives can be prepared in quantities ranging from milligrams to multi‐grams. The use of inexpensive starting materials and reagents makes the method both cost‐effective and accessible for large‐scale synthesis. Good and consistent yield of the product, operational ease, and environmental benignity make the method more acceptable and applicable in organic synthesis.