One-pot three-component synthesis of 6-aryl-3-(arylamino)-5H-thiazolo[3',2':1,2]pyrimido[4,5-b]quinolines utilizing 4-amino-6-oxo-pyrimidin-tethered N-aryl-2-mercaptoacetamides as precursors

New thiazolo[3',2':1,2]pyrimido [4,5-b]quinolines were synthesized in good yields using a three-component Hantzsch reaction comprising the appropriate aldehyde and one mole each of 6-aminothiouracil and 5,5dimethyl-1,3-cyclohexanedione.The identical compounds might also be generated by alkylating the relevant 5-aryl-2-thioxopyrimido[4,5-b]quinoline-4,6-diones with the matching 2-chloro-N-arylacetamide.A feasible mechanistic approach to the production of the target products was proposed.