One-pot Three-component Synthesis of New Pyridine-fused Pyranoquinoline Derivatives

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A new series of pyridine-fused pyranoquinoline derivatives have been synthesized via onepot three-component coupling of hydroxyquinoline, aromatic aldehydes, and 2-aminopropene-1,1,3- tricarbonitrile in the presence of 10 mol% of triethylamine at 80°C in ethanol under reflux conditions. It is an effective synthetic method due to its simple operating procedure, wide range of substrates, column chromatography-free separations, and high product yield.