P01 - Evaluation of the preoperative and early postoperative laboratory parameters in terms of biochemical remission in patients with acromegaly

Background/Introduction This study aimed to determine the factors predicting postoperative biochemical remission in patients with acromegaly who underwent transsphenoidal surgery. Methods This single-center retrospective study included patients diagnosed with treatment-naive acromegaly. Preoperative and early postoperative days (postoperative days 2-4) serum levels of growth hormone (GH), insulin-like growth factor 1 (IGF-1), IGF-1 standardized to the upper limit of normal (IGF-1 ULN), calcium and phosphorus were obtained from hospital records. Patients were divided into two groups according to their biochemical remission status within 3-6 months after transsphenoidal surgery. Results Of the 68 patients who underwent surgery, 44 (64.7%) achieved biochemical remission. Preoperative GH, IGF-1, and IGF-1 ULN levels were significantly higher in the non-remission group compared to those who achieved remission (p<0.005). Although preoperative calcium levels were significantly different between groups (p=0.006), phosphorus levels were not (p=0.248). GH, IGF-1, IGF-1 ULN, calcium, and phosphorus levels measured in the early postoperative days were significantly lower in the remission group (all p < 0.05). GH level in the early postoperative days was significantly correlated with IGF-1 (p < 0.001), IGF-1 ULN (p < 0.001) and phosphorus (p < 0.05). IGF-1 ULN was also correlated with early postoperative calcium (p < 0.05) and phosphorus levels (p <0.05). Conclusion(s) Monitoring IGF-1, GH, calcium, and phosphorus levels in the early postoperative period may contribute to the evaluation of biochemical remission in patients with acromegaly.