Research reveals combining morphine with methadone improves therapeutic dose attainment in patients facing fentanyl challenges.
In the fentanyl era, higher doses of methadone or buprenorphine are needed for many patients, researches have found. A study published last month found that initiating methadone treatment at higher doses and in combination with slow‐release oral morphine improve faster attainment of therapeutic doses of morphine.
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Alison Knopf (2025) studied this question.
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