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September 23, 2025Frontiers in EndocrinologyOpen Access

Alterations in peripheral CD4+ T cell subsets and their association with metabolic markers in obese children

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Authors

RSReiko SaitoUniversity of Niigata PrefectureJHJun HirakawaUniversity of Occupational and Environmental Health JapanMKMami KuwamuraUniversity of Occupational and Environmental Health Japan

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Overview

Prospective study shows altered cd4 t cell subsets in obese children, suggesting immune dysregulation.

Key Points

  • Obese children exhibited significantly lower proportions of cd4 t cells compared to non-obese controls, indicating altered immune profiles.
  • The ratio of naïve to memory cd4 t cells was also significantly lower in obese children, with regulatory t cells being higher, thus affecting immune response.
  • Metabolic markers, such as serum insulin and blood glucose levels, correlated with specific t cell populations and suggest altered metabolic health.
  • Findings underscore the need for understanding immune mechanisms in childhood obesity to address long-term health implications.

Cite This Study

Saito et al. (2025) studied this question.

synapsesocial.com/papers/68d4726431b076d99fa6b88dhttps://doi.org/10.3389/fendo.2025.1635379
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