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January 1, 2015Obesity FactsOpen Access

Obese young adults had significantly higher peripheral total leukocyte and monocyte counts compared to normal-weight controls, which correlated with insulin resistance and liver enzymes.

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Population

23 young adults, comprising 12 obese and 11 normal weight.

Design

Cross-sectional

Key result

Obese young adults had significantly higher peripheral total leukocyte and monocyte counts compared to normal-weight controls, which correlated with insulin resistance and liver enzymes.

Authors

AYAya YoshimuraFujita Health UniversitySOShunsuke OhnishiHokkaido UniversityCOChieko Orito

Discussion

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Overview

Supports low-grade inflammation in obese youth; hypothesis-generating and requires longitudinal confirmation before clinical use.

Study Design

Type

Cross-Sectional (n=23)

Multicenter

No

Structured PICO

P
Population
23 young adults (12 obese and 11 normal weight) were evaluated to assess the association between peripheral leukocyte counts and obesity-related complications.
O
Outcome
Association between peripheral total and differential leukocyte counts and obesity-related complications (liver enzymes, fasting blood glucose, insulin, lipids, insulin resistance, fat mass, fat thickness, fatty liver)surrogate

Main Result

Absolute Event Rate: 7120% vs 5060%

p-value: p=<0.05

Chronic low-grade systemic inflammation, indicated by elevated leukocyte and monocyte counts, is associated with obesity-related complications such as NAFLD, insulin resistance, and dyslipidemia in young adults.

Limitations

  • Small number of subjects

Cite This Study

Yoshimura et al. (2015) conducted a cross-sectional in Obesity (n=23). Obesity (BMI ≥ 35 kg/m2) vs. Normal weight (BMI 20-22 kg/m2) was evaluated on Peripheral total leukocyte count (cells/μl) (p=<0.05). Obese young adults had significantly higher peripheral total leukocyte and monocyte counts compared to normal-weight controls, which correlated with insulin resistance and liver enzymes.

synapsesocial.com/papers/6a97ba31c5cc395bb1e17178https://doi.org/10.1159/000373881
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessments of the Relationship Between Inflammatory Parameters from Complete Blood Count and Clinical Findings in Children with Obesity and Comparison with Healthy Children2025 · 1 citations
  2. 2Characterizing Human Peripheral Blood Lymphocyte Phenotypes and Their Correlations with Body Composition in Normal-Weight, Overweight, and Obese Healthy Young Adults2024 · 3 citations
  3. 3Alterations in peripheral CD4+ T cell subsets and their association with metabolic markers in obese children2025
  4. 4The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity2023 · 16 citations
  5. 5A systematic evaluation of T lymphocytes and metabolic parameters in childhood obesity: new therapeutic targets for the disease? 23082102026