Key result
Children with obesity had significantly higher inflammatory hematological parameters, including neutrophil/lymphocyte and platelet/lymphocyte ratios, compared to healthy children (P < 0.05).
Why the study?
The study aimed to compare hematological inflammatory parameters between children with obesity and healthy controls, and to evaluate their relationship with clinical findings in children with obesity.
Are hematological inflammatory parameters elevated in children with obesity compared to healthy children, and do they correlate with clinical findings?
Comparison
Children with obesity vs healthy non-obese children
Design
Observational case-control study
Authors
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Obesity-linked elevations in pediatric NLR/PLR are hypothesis-generating; should not change practice or risk stratification without prospective validation.
Observational (n=128)
Are hematological inflammatory parameters elevated in children with obesity compared to healthy children, and do they correlate with clinical findings?
p-value: p=<0.05
Hematological parameters from a standard complete blood count, such as PLR and NLR, are elevated in children with obesity and correlate with clinical findings like fatty liver disease and acanthosis nigricans, serving as potential indicators of chronic inflammation.
Çömlek et al. (2025) conducted an observational in Obesity (n=128). Obesity vs. Healthy children (non-obesity) was evaluated on Hematological parameters including NLR, PLR, RDW, and cell counts (p=<0.05). Children with obesity had significantly higher inflammatory hematological parameters, including neutrophil/lymphocyte and platelet/lymphocyte ratios, compared to healthy children (P < 0.05).
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