Features of concentrations of endothelin-1, biologically active vasomotor amines and hormones in practically healthy residents of the North

Objective. To establish the features and interrelations of concentrations of endothelin-1, biologically active vasomotor amines and hormones in the blood of residents of the northern territories. Material and methods. 499 practically healthy people aged 25–55 years living in the Arkhangelsk, Murmansk regions; Nenets Autonomous Okrug, Komi Republic (Svetlogorsk) and the Svalbard archipelago (Barentsburg settlement) were examined. Serum concentrations of endothelin-1, serotonin, norepinephrine, adrenaline, dopamine, adrenocorticotropic hormone (ACTH), thyroxine, cortisol, thyrotropin (TSH), somatotropic hormone (STH) were determined by enzyme immunoassay. Results. In practically healthy residents of the Arctic, compared with people living in territories equated to the regions of the Far North, a high frequency of registration of elevated blood concentrations of endothelin-1 (55.79 and 35.34%), serotonin (28.76 and 19.55%), norepinephrine (30.04 and 16.92%), as well as significant levels of elevated concentrations was established dopamine (13.30 and 9.77%;), adrenaline (6.44 and 3.02%), ACTH (9.76 and 5.79%), cortisol (8.13 and 4.96%) and STH (10.57 and 5.79%); p < 0.01–0.001. Conclusion. Serotonin, initiating vascular reactions together with endothelin-1, determines the direction of its further development, supporting synaptic excitation or providing inhibition. The high level of coincidence of elevated concentrations of serotonin and norepinephrine in 81 out of 115 people (70.43%) indicates that norepinephrine supports the regulation of the vascular bed caused by serotonin, prolonging or enhancing it. An increase in the concentration of adrenaline against the background of increased concentrations of norepinephrine (in 8 out of 115 people; 6.96%) causes the risk of an increase in total peripheral vascular resistance and vascular resistance in the kidneys. An increase in the concentration of dopamine above physiological limits is an expression of the need for processes to inhibit the mechanisms of regulation of hemodynamic reactions. Simultaneous increased concentrations of catecholamines and cortisol increase the tension of regulatory mechanisms with the formation of a state of readiness for stress (allostasis). Increases in ACTH, STH, and cortisol in the blood reflect metabolic changes that require both correction and control.