January 1, 1988Japanese Circulation Journal-english EditionOpen Access

Evidence for increased sympatho-adrenomedullary activity in young subjects with borderline hypertension.

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Why the study?

Do young subjects with borderline hypertension have increased sympatho-adrenomedullary activity in response to stress compared to normotensive subjects?

Population

64 young subjects, comprising 40 with borderline hypertension and 24 age-matched normotensive subjects.

Comparison

Physiological stressors including isometric… vs Age-matched normotensive subjects undergoing the…

Design

Cross-sectional

Authors

YIYasushi ItoJapan Aerospace Exploration Agency KAKatsuyuki AndoSeiwa Hospital HNHiroshi NodaNational Institute of Technology, Niihama College

Discussion

Member takes

Implication

Augmented sympatho-adrenomedullary reactivity in borderline hypertension is hypothesis-generating; prospective studies needed before clinical relevance.

Structured PICO

Do young subjects with borderline hypertension have increased sympatho-adrenomedullary activity in response to stress compared to normotensive subjects?

Population

64 young subjects, comprising 40 with borderline hypertension (BHT) and 24 age-matched normotensive subjects (NT).

Intervention

Physiological stressors including isometric handgrip exercise, intravenous glucagon injection (1 USP unit), and intravenous norepinephrine infusion (100 and 200 ng/kg/min for 15 min).

Comparator

Age-matched normotensive subjects undergoing the same physiological stressors.

Outcome

Plasma catecholamine levels (total catecholamines, epinephrine) and blood pressure responses to stressors.surrogate

Young subjects with borderline hypertension exhibit augmented sympathetic nervous system and adrenal medulla responses to stress without increased vascular reactivity to norepinephrine.

Cite This Study

Ito et al. (1988) studied this question.

synapsesocial.com/papers/6a8a42a5238a34ecf4722145 https://doi.org/10.1253/jcj.52.1326

Topics

Hypertension management

View Full Paper

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January 1, 1988Japanese Circulation Journal-english EditionOpen Access

Evidence for increased sympatho-adrenomedullary activity in young subjects with borderline hypertension.

View Full Paper

Ask AI

Bookmark

Why the study?

Do young subjects with borderline hypertension have increased sympatho-adrenomedullary activity in response to stress compared to normotensive subjects?

Population

64 young subjects, comprising 40 with borderline hypertension and 24 age-matched normotensive subjects.

Comparison

Physiological stressors including isometric… vs Age-matched normotensive subjects undergoing the…

Design

Cross-sectional

Authors

YIYasushi ItoJapan Aerospace Exploration Agency KAKatsuyuki AndoSeiwa Hospital HNHiroshi NodaNational Institute of Technology, Niihama College

Discussion

Member takes

Implication

Augmented sympatho-adrenomedullary reactivity in borderline hypertension is hypothesis-generating; prospective studies needed before clinical relevance.

Structured PICO

Do young subjects with borderline hypertension have increased sympatho-adrenomedullary activity in response to stress compared to normotensive subjects?

Population

64 young subjects, comprising 40 with borderline hypertension (BHT) and 24 age-matched normotensive subjects (NT).

Intervention

Physiological stressors including isometric handgrip exercise, intravenous glucagon injection (1 USP unit), and intravenous norepinephrine infusion (100 and 200 ng/kg/min for 15 min).

Comparator

Age-matched normotensive subjects undergoing the same physiological stressors.

Outcome

Plasma catecholamine levels (total catecholamines, epinephrine) and blood pressure responses to stressors.surrogate

Young subjects with borderline hypertension exhibit augmented sympathetic nervous system and adrenal medulla responses to stress without increased vascular reactivity to norepinephrine.

Cite This Study

Ito et al. (1988) studied this question.

synapsesocial.com/papers/6a8a42a5238a34ecf4722145 https://doi.org/10.1253/jcj.52.1326

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Hypertension management

View Full Paper

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