Increased Sympatho-Adrenomedullary Activity in Young Patients with Borderline Hypertension
Why the study?
Does sympatho-adrenomedullary activity differ in young patients with borderline hypertension compared to normotensive subjects during stress?
Population
32 young subjects, comprising 23 patients with borderline hypertension and 9 age-matched normotensive…
Comparison
Isometric stress and intravenous glucagon… vs Age-matched normotensive subjects undergoing the…
Design
Case-control
Authors
Discussion
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Implication
Augmented catecholamine responses in borderline hypertension support mechanistic inquiry; hypothesis-generating and should not change practice.
Structured PICO
Does sympatho-adrenomedullary activity differ in young patients with borderline hypertension compared to normotensive subjects during stress?
P
Population
32 young subjects, comprising 23 patients with borderline hypertension (BHT) and 9 age-matched normotensive subjects (NT).
I
Intervention
Isometric stress (handgrip at 30% maximal voluntary contraction for 3 minutes) and intravenous glucagon injection (1 USP unit).
C
Comparator
Age-matched normotensive subjects undergoing the same stress tests.
O
Outcome
Plasma total catecholamine response to isometric exercise and plasma epinephrine response to glucagon injection.surrogate
Young patients with borderline hypertension exhibit augmented sympatho-adrenomedullary responses to stress, suggesting a mechanism that may contribute to the development of essential hypertension.
Cite This Study
Ito et al. (1987) studied this question.