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August 1, 1983Journal of Hypertension

Circulatory and Sympatho-adrenal Responses to Stress in Borderline and Established Hypertension

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Why the study?

Do circulatory and sympatho-adrenal responses to stress provocations differ between patients with borderline or established hypertension and normotensive controls?

Population

66 subjects: 33 with essential hypertension, 16 with borderline hypertension, and 17 age and sex-matched…

Comparison

Stress provocations including mental stress… vs Normotensive controls (NT).

Design

Cross-sectional

Authors

KEKeith EliassonKarolinska University HospitalPHPaul HjemdahlPreventive CardiologyTKThomas KahanPreventive Cardiology

Discussion

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Implication

Hypothesis-generating for heightened stress reactivity in early hypertension; leaves open whether adrenaline responses improve risk stratification or warrant intervention.

Structured PICO

Do circulatory and sympatho-adrenal responses to stress provocations differ between patients with borderline or established hypertension and normotensive controls?

P
Population
66 subjects: 33 with essential hypertension (EHT), 16 with borderline hypertension (BHT), and 17 age and sex-matched normotensive controls (NT).
I
Intervention
Stress provocations including mental stress (colour word test [CWT]), orthostatic testing (ORT), and a cold pressor test (CPT).
C
Comparator
Normotensive controls (NT).
O
Outcome
Circulatory responses (blood pressure, heart rate) and sympatho-adrenal responses (venous plasma noradrenaline [NA] and plasma adrenaline [ADR]).surrogate

Early hypertension is associated with enhanced cardiovascular and sympatho-adrenal reactivity to mental stress, with plasma adrenaline serving as a more valuable marker than venous plasma noradrenaline.

Cite This Study

Eliasson et al. (1983) studied this question.

synapsesocial.com/papers/6a08caee96b78901e666c208https://doi.org/10.1097/00004872-198308000-00004

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CARDIOVASCULAR, ELECTRODERMAL AND CATECHOLAMINE RESPONSES TO STRESS IN BORDERLINE HYPERTENSIVES1996 · 1 citations
  2. 2STANDING AND MENTAL STRESS TESTS IN NORMAL YOUNG SUBJECTS AND ESSENTIAL HYPERTENSION WITH SPECIAL REFERENCE TO THE GENETIC PREDISPOSITION TO HYPERTENSION AND ADRENO-SYMPATHETIC ACTIVITY1988
  3. 3Increased Sympatho-Adrenomedullary Activity in Young Patients with Borderline Hypertension1987
  4. 4Evidence for increased sympatho-adrenomedullary activity in young subjects with borderline hypertension.1988 · 2 citations
  5. 5Physiological Determinants of Hyperreactivity to Stress in Borderline Hypertension1995 · 66 citations