Key result
Hypertensive family history linked to ~3.5-fold higher risk of exaggerated mental stress blood pressure reactivity.
Why the study?
The role of genetic predisposition to hypertension in determining plasma catecholamine levels and responsiveness to standing and mental stress was unclear.
How do standing and mental stress affect blood pressure, pulse rate, and adreno-sympathetic activity in subjects with varying genetic predispositions to and stages of hypertension?
Cross-Sectional (n=56)
No
How do standing and mental stress affect blood pressure, pulse rate, and adreno-sympathetic activity in subjects with varying genetic predispositions to and stages of hypertension?
Absolute Event Rate: 50% vs 14.3%
Genetic predisposition to hypertension significantly influences plasma catecholamine levels and cardiovascular responsiveness to mental stress.
No takes yet. Share an insight, caveat, or question.
Suggests familial hypertension history augments mental stress BP reactivity; hypothesis-generating and should not yet alter clinical practice.
Y. Horikoshi (1988) conducted a cross-sectional in Essential hypertension and genetic predisposition to hypertension (n=56). Genetic predisposition to hypertension and hypertension status vs. Normotensive subjects without hypertensive parents was evaluated on Incidence of systolic blood pressure increase ≥20 mmHg in response to mental stress (higher responders). A systolic blood pressure increase of 20 mmHg or more during mental stress occurred more frequently in normotensive subjects with hypertensive parents (50%) compared to those without (14.3%).
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