Key result
Resting plasma norepinephrine levels were significantly higher in children with borderline (454 pg/ml, p<0.001) and significant hypertension (384 pg/ml, p<0.01) than in normotensive controls.
Why the study?
Does orthostatic stress of quiet standing alter blood pressure, heart rate, and plasma catecholamines differently in hypertensive children and their siblings compared to normotensive controls?
Population
63 children, including 19 with borderline hypertension, 9 with significant hypertension, 14 normotensive…
Comparison
Orthostatic stress of quiet standing vs Rest
Design
Cross-sectional
Authors
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Sympathetic overactivity may contribute to early hypertension; hypothesis-generating for causal and longitudinal studies.
Observational (n=63)
Does orthostatic stress of quiet standing alter blood pressure, heart rate, and plasma catecholamines differently in hypertensive children and their siblings compared to normotensive controls?
Absolute Event Rate: 454% vs 281%
p-value: p=<0.001
Altered adrenergic sympathetic nervous system activity is present in a subgroup of young hypertensives and may contribute to their hypertension, with genetic factors potentially involved.
McCrory et al. (1982) conducted an observational in Hypertension (n=63). Borderline or significant hypertension vs. Normotensive controls was evaluated on Resting plasma norepinephrine (NE) levels (p=<0.001). Resting plasma norepinephrine levels were significantly higher in children with borderline (454 pg/ml, p<0.001) and significant hypertension (384 pg/ml, p<0.01) than in normotensive controls.
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