Why the study?
Does plasma adrenaline modulate alpha-1-adrenoceptor mediated pressor responses and baroreflex control in patients with borderline hypertension compared to normotensive subjects?
Population
20 subjects (10 patients with borderline hypertension and 10 age-matched normotensive subjects)
Comparison
Intravenous infusion of at least three graded… vs Age-matched normotensive subjects receiving the…
Design
Case-control
Authors
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May link adrenaline to heightened alpha-1 pressor sensitivity in borderline hypertension; hypothesis-generating and requires prospective confirmation before clinical relevance.
Does plasma adrenaline modulate alpha-1-adrenoceptor mediated pressor responses and baroreflex control in patients with borderline hypertension compared to normotensive subjects?
In patients with borderline hypertension, elevated resting plasma adrenaline correlates with exaggerated pressor responses to alpha-1-adrenoceptor stimulation and reduced baroreflex sensitivity.
Minatoguchi et al. (1995) studied this question.
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