Key result
Borderline hypertension shows no link to increased sympathetic activity compared to normotensive volunteers.
Why the study?
The relationship between sympathetic nervous system activity and renin-angiotensin system activity in subjects with borderline hypertension compared to normotensive volunteers was unclear.
Are plasma catecholamine levels and renin activity increased in subjects with borderline hypertension compared to normotensive volunteers?
Population
Subjects with borderline hypertension and normotensive volunteers
Comparison
Borderline hypertension vs normotensive volunteers
Design
Observational study measuring plasma catecholamines and renin activity at rest and during exercise
Authors
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Borderline hypertension lacks sympathetic activation; leaves open mechanisms of progression to sustained hypertension.
Observational
Are plasma catecholamine levels and renin activity increased in subjects with borderline hypertension compared to normotensive volunteers?
The study finds no evidence of increased sympathetic activity or renin-angiotensin system activation in borderline hypertension compared to normotensive controls.
Henquet et al. (1981) conducted an observational in Borderline hypertension. Borderline hypertension vs. Normotensive volunteers was evaluated on Plasma concentrations of noradrenaline and adrenaline, plasma renin activity, and plasma renin concentration. Borderline hypertension was not associated with increased sympathetic activity, as plasma catecholamines and renin levels did not differ from normotensive volunteers at rest or during exercise.
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