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January 1, 1981Clinical and experimental hypertension

Inter-Relationship of Sympathetic Nervous System and Renin-Angiotensin-Aldosterone System in three Renin Subgroups of Borderline and Persistent Essential Hypertension

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Why the study?

Does volume depletion alter sympathetic and renin activity differently in borderline versus persistent essential hypertension?

Population

51 patients categorized as borderline or persistent hypertensives and as high, normal, or low renin.

Comparison

Volume depletion via standing plus furosemide… vs Comparisons between borderline and persistent…

Design

Cohort

Authors

KMKeiji MikamiTNTetsuo NishikawaYTYasushi Tamura

Discussion

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Overview

Differential volume depletion responses by renin subgroup in borderline hypertension are hypothesis-generating; prospective trials needed before clinical consideration.

Structured PICO

Does volume depletion alter sympathetic and renin activity differently in borderline versus persistent essential hypertension?

P
Population
51 patients categorized as borderline or persistent hypertensives and as high, normal, or low renin.
I
Intervention
Volume depletion via standing plus furosemide, and dietary sodium restriction
C
Comparator
Comparisons between borderline and persistent hypertensive subgroups, and across high, normal, or low renin profiles
O
Outcome
Changes in blood pressure, plasma renin activity (PRA), dopamine beta-hydroxylase (DBH) activity, and plasma aldosterone concentrationsurrogate

Borderline hypertensives exhibit a greater increase in sympathetic and renin activity in response to volume depletion compared to persistent hypertensives.

Cite This Study

Mikami et al. (1981) studied this question.

synapsesocial.com/papers/6a228107b04f494b2753ff27https://doi.org/10.3109/10641968109037426
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