Why the study?
How do circulatory volumes and plasma renin activity relate to blood pressure in young patients with borderline hypertension?
Population
15 normal subjects and 25 young patients with borderline hypertension
Comparison
Equilibration on controlled sodium intake vs Normotensive controls (15 normal subjects)
Design
Case-control
Key result
Borderline hypertension was associated with consistently lower total blood and plasma volumes and higher plasma renin activity compared to normotensive controls.
Authors
Loading...
Hypothesis-generating for sympathetic involvement in young borderline hypertension; leaves open causal direction and need for prospective validation.
Cross-Sectional (n=40)
How do circulatory volumes and plasma renin activity relate to blood pressure in young patients with borderline hypertension?
Borderline hypertension is associated with lower circulatory volumes and higher plasma renin activity, suggesting a common causal factor such as sympathetic nervous system hyperresponsiveness.
Lebel et al. (1981) conducted a cross-sectional in Borderline essential hypertension (n=40). Borderline essential hypertension vs. Normotensive controls was evaluated on Total blood volume, plasma volume, and plasma renin activity. Borderline hypertension was associated with consistently lower total blood and plasma volumes and higher plasma renin activity compared to normotensive controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: