Harnessing Microbial Power for a Sustainable Future Food System

Microorganisms are transforming the way we address sustainability across agriculture, food production, waste remediation, bioenergy, and industrial bioprocessing, offering novel solutions for the food systems of tomorrow. This systematic review examines literature from the last twenty years in order to identify key advances, challenges, and future directions in harnessing microbial systems for sustainable applications, especially those underpinning a resilient future food system. The selected documents allowed a mapping of the most important trends: innovations based on metabolic engineering and omics, the use of integrated biorefineries, and digital monitoring platforms are emerging as catalysts for the transition, while high scaling costs, regulatory challenges, and low public acceptance continue to limit large-scale implementation. The analysis highlights both the major advantages (reducing ecological impact, valorizing waste, diversifying food sources) and the current limits of these technologies, proposing a multi-stakeholder roadmap to accelerate the transition to a circular bioeconomy and a low-carbon and climate-resilient food system.