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September 23, 2025Current Issues in Molecular BiologyOpen Access

Bioactive Component Screening and Mechanistic Study of the Anti-Diabetic Activity of Lophatherum gracile Brongn Extract

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Authors

RWRong WangChinese Academy of SciencesXLXuefeng LiuXiamen UniversityKYKuan YangNorthwestern Polytechnical University

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Implication

Mechanistic analysis reveals bioactive components in Lophatherum gracile Brongn modulate gut microbiota and improve metabolic dysfunction in T2DM.

Key Points

  • Lophatherum gracile Brongn improved glucose and lipid metabolism in T2DM models, significantly reducing hyperglycemia.
  • Utilizing metabolomics, three key bioactive components—isoorientin, orientin, and isovitexin—were identified for their hypoglycemic activity.
  • The study included analysis of microbial shifts, showing increased Lactobacillales and Bacteroides linked to SCFA elevation in treatment.
  • By modulating the LPS/TLR4/NF-κB pathway, LGB potentially alleviates intestinal inflammation and supports tight junction integrity.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d473ad31b076d99fa6c26dhttps://doi.org/10.3390/cimb47090779
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