Monte Carlo simulations indicate epetraborole dosing fails to ensure Mycobacterium tuberculosis treatment efficacy.
In the hollow fiber system model of tuberculosis (TB), the ratio of area under the concentration-time curve to MIC (AUC 0-24 /MIC) of 327.1 was identified as the epetraborole optimal exposure target for Mycobacterium tuberculosis kill. Monte Carlo simulation experiments showed that even the intravenous dose of 1,500 mg/twice daily would fail in the majority of patients, and the dose needed for good efficacy for TB may likely not be safe for patients.
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Singh et al. (2025) studied this question.
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