September 23, 2025Open Access

Cross-species phenotypic profiling uncovers functional determinants of bacterial cold shock adaptation

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Authors

HFHao FanSouth China Agricultural University ABAndrew BriercheckUniversity of Illinois Urbana-Champaign VMVivek K. MutalikLawrence Berkeley National Laboratory

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Implication

Transposon sequencing identifies essential genes for cold shock adaptation in Escherichia coli and Bacillus subtilis, suggesting shared and unique mechanisms.

Key Points

The study reveals a structured program for cold shock response in Bacillus subtilis, emphasizing membrane fluidity early on.
Importantly, mutants lacking RsmA and RsmH showed a delayed recovery in translation after cold exposure.
Phenotypic profiling combined with transposon sequencing demonstrates critical pathways in bacterial cold adaptation.
Findings enhance understanding of stress responses in both pathogens and extremophiles, with practical implications for biotechnology.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/68d473bb31b076d99fa6c9a3 https://doi.org/10.1101/2025.09.22.676666

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Implication

Transposon sequencing identifies essential genes for cold shock adaptation in Escherichia coli and Bacillus subtilis, suggesting shared and unique mechanisms.

Cross-species phenotypic profiling uncovers functional determinants of bacterial cold shock adaptation

Discussion

Member takes

Implication

Key Points

Cite This Study

Cross-species phenotypic profiling uncovers functional determinants of bacterial cold shock adaptation

Discussion

Member takes

Implication

Key Points

Cite This Study

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