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September 30, 2025BiomoleculesOpen Access

Cold Shock Proteins Mediate Transcription of Ribosomal RNA in Escherichia coli Under Cold-Stress Conditions

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Observational analysis reveals cold shock proteins impact ribosomal RNA synthesis in Escherichia coli, suggesting adaptive mechanisms.

CspA, CspE, and CspI deletion affects rRNA synthesis in Escherichia coli during cold stress.
Double and triple deletions lead to a significant reduction in 16S rRNA synthesis and growth.
Cold shock proteins act as crucial support mechanisms for ribosome biogenesis at low temperatures.
Findings highlight the existence of backup systems that compensate for individual CSP loss.

Li et al. (2025) studied this question.

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