Cationic iridium(III) complexes with a halogen-substituted pyridylbenzimidazole ancillary ligand for photodynamic therapy

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This is a Experimental Study study.

Pierre‐Henri Lanoë; Frédérique Loiseau; Christian Philouze; Camille Latouche; Laeticia Falcon; Louis Biancon; Ahmed Sabah aldoori; Florian Molton; Matéo Lavaud; Anne‐Laure Bulin; Jean‐Luc Coll; Ákos Bányász; Amandine Hurbin

doi:10.1039/d5ma00964b

January 1, 2025Materials AdvancesOpen Access

Cationic iridium(III) complexes with a halogen-substituted pyridylbenzimidazole ancillary ligand for photodynamic therapy

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Key Points

Light irradiation generates oxidative stress, inducing cell death through apoptosis and necrosis.
Cationic iridium(III) complexes exhibit high efficiency in type II photodynamic therapy applications.
The presence of a halogen-substituted pyridylbenzimidazole ligand enhances the properties of these complexes.
Innovative photodynamic therapy involving these complexes may lead to improved cancer treatment outcomes.

Implication

This research demonstrates cationic iridium(III) complexes improve apoptosis and necrosis in PDT, suggesting enhanced therapeutic potential.

Abstract

PhotoDynamic Therapy (PDT) is a powerful technique, as the oxidative stress generated by light irradiation causes cell death through apoptosis and necrosis. In type II PDT, iridium(III) complexes displaying high...

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Cite This Study

Lanoë et al. (2025) studied this question.

synapsesocial.com/papers/68d4757f31b076d99fa6cda1 https://doi.org/10.1039/d5ma00964b

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Cationic iridium(III) complexes with a halogen-substituted pyridylbenzimidazole ancillary ligand for photodynamic therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Cationic iridium(III) complexes with a halogen-substituted pyridylbenzimidazole ancillary ligand for photodynamic therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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