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September 23, 2025Frontiers in Molecular BiosciencesOpen Access

Integrated analysis and experimental validation of E2F2 as a potential prognostic biomarker and its oncogenic roles in serous ovarian cancer

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Authors

FJFengyin JiangFHFei HeFujian Medical UniversityLYLina YangPeking University

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Implication

This analysis investigates E2F2's role in immune cell infiltration and chemotherapy response in serous ovarian cancer, indicating its potential as a prognostic biomarker.

Key Points

  • High e2f2 expression is linked to worse overall survival and increased tumor grade in patients with serous ovarian cancer.
  • Bioinformatics analysis demonstrated that e2f2 correlates with immune cell recruitment, affecting treatment strategies for ovarian cancer.
  • Experimental validation showed that e2f2 promotes cell metastasis and sensitivity to chemotherapy, enhancing prospects for targeted therapy.
  • E2F2 acts as an independent risk factor, suggesting its utility in patient stratification and personalized treatment plans.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68d4757f31b076d99fa6ce3bhttps://doi.org/10.3389/fmolb.2025.1661558
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