September 23, 2025Journal of Agricultural and Food Chemistry

Discovery of Aromatic Amide Derivatives Bearing Oxime Ethers Targeting Succinate Dehydrogenase

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ZHZesheng Hao JHJintao Han YZYue Zhang

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Overview

Fungicidal bioassays revealed new aromatic amide derivatives, targeting succinate dehydrogenase, suggesting enhanced activity against Rhizoctonia solani.

Key Points

Compound I-9 exhibits exceptional fungicidal activity with an EC50 of 0.07 μg/mL against Rhizoctonia solani, surpassing trifloxystrobin.
Molecular docking studies indicated compound I-9 effectively binds to the active site of succinate dehydrogenase, confirming its potential as a lead compound.
In vivo tests demonstrated I-9's excellent performance at 200 μg/mL, comparable to leading fungicides such as thifluzamide and fluxapyroxad.
The promising enzyme inhibition (IC50 of 0.35 μg/mL) of I-9 against RsSDH indicates its viability as a candidate SDHI fungicide.

Cite This Study

Hao et al. (2025) studied this question.

synapsesocial.com/papers/68d4759031b076d99fa6d414 https://doi.org/10.1021/acs.jafc.5c02252

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September 23, 2025Journal of Agricultural and Food Chemistry

Discovery of Aromatic Amide Derivatives Bearing Oxime Ethers Targeting Succinate Dehydrogenase

View Full Paper

Ask AI

Bookmark

Authors

ZHZesheng Hao JHJintao Han YZYue Zhang

Discussion

Member takes

Overview

Fungicidal bioassays revealed new aromatic amide derivatives, targeting succinate dehydrogenase, suggesting enhanced activity against Rhizoctonia solani.

Key Points

Compound I-9 exhibits exceptional fungicidal activity with an EC50 of 0.07 μg/mL against Rhizoctonia solani, surpassing trifloxystrobin.
Molecular docking studies indicated compound I-9 effectively binds to the active site of succinate dehydrogenase, confirming its potential as a lead compound.
In vivo tests demonstrated I-9's excellent performance at 200 μg/mL, comparable to leading fungicides such as thifluzamide and fluxapyroxad.
The promising enzyme inhibition (IC50 of 0.35 μg/mL) of I-9 against RsSDH indicates its viability as a candidate SDHI fungicide.

Cite This Study

Hao et al. (2025) studied this question.

synapsesocial.com/papers/68d4759031b076d99fa6d414 https://doi.org/10.1021/acs.jafc.5c02252

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