September 23, 2025

Human epidermal growth factor receptor 2 and proliferation Ki-67 biomarkers using a tissue microarray to refine the histopathological subtyping of hydatidiform moles: Limitations and prognostic value.

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Ambispective study identifies Ki-67 and HER2 markers' potential for refining hydatidiform mole subtypes and prognostic value.

A significant trend shows increased Ki-67 immunostaining in complete hydatidiform mole samples, indicating its role as a prognostic marker.
Out of 108 hydatidiform mole cases, 17 patients developed gestational trophoblastic neoplasia, with several having high Ki-67 scores.
Immunostaining analysis via tissue microarray explored the relationship between HER2 scores and clinical outcomes in hydatidiform moles.
The study highlights caution in interpreting results due to a small sample size and a high rate of sample exclusion.

López et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark