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September 23, 2025A&A Practice

Genetic Pseudocholinesterase Deficiency Unmasked After Succinylcholine-Rivastigmine Interaction: A Case Report

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Case report highlights succinylcholine apnea following rivastigmine treatment, indicating important drug interactions.

The combination of succinylcholine and rivastigmine unmasked a genetic pseudocholinesterase deficiency in a patient undergoing ECT.
Following the incident, subsequent treatments with low-dose rocuronium proved effective, minimizing complications.
Clinicians should be aware of interactions between cholinesterase inhibitors and succinylcholine in anesthesia settings.
This case emphasizes the need for careful monitoring and alternative options in patients with potential genetic deficiencies.

Ho et al. (2025) studied this question.

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