Key result
Succinylcholine triggers 8-hour neuromuscular blockade in undiagnosed atypical pseudocholinesterase deficiency.
Why the study?
When evaluating delayed emergence from anesthesia, pseudocholinesterase deficiency is an insidious cause with diagnostic challenges, and family history is often overlooked.
Population
One 90-year-old female undergoing hip arthroplasty
Design
Case report
Authors
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Prolonged succinylcholine blockade may signal undiagnosed pseudocholinesterase deficiency; this case leaves open the value of targeted preoperative testing.
Case Report (n=1)
No
This case highlights the importance of considering pseudocholinesterase deficiency and obtaining a thorough family history in patients with delayed emergence from anesthesia after succinylcholine use.
Hubbell et al. (2025) conducted a case report in Pseudocholinesterase deficiency (n=1). Succinylcholine was evaluated on Duration of neuromuscular blockade. Administration of succinylcholine in a 90-year-old female with an undiagnosed heterozygous atypical pseudocholinesterase deficiency resulted in an eight-hour prolonged neuromuscular blockade.
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