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September 15, 2025Anatolian Current Medical JournalOpen Access

Impact of JAK2 V617F allele burden on clinical and laboratory parameters in polycythemia vera

Özlem Beyler Cengiz Demır

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Key Points

Higher JAK2 V617F allele burden is linked to increased thrombotic events in polycythemia vera patients.
In the study, significant associations were observed between allele burden and systemic inflammatory markers.
The analysis used quantitative PCR to measure the JAK2 V617F allele burden across 71 PV patients.
Findings may support tailored management strategies for patients with varying levels of JAK2 V617F allele burden.

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Implication

Retrospective analysis shows JAK2 V617F allele burden correlates with thrombotic events and disease severity.

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Cite This Study

Beyler et al. (2025) studied this question.

synapsesocial.com/papers/68d475a031b076d99fa6de32 https://doi.org/10.38053/acmj.1715880

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