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September 23, 2025Annual Research & Review in Biology

Urinary and Blood microRNAs miR-21, miR-141 and miR-375 as Potential Diagnostic Biomarkers for Prostate Cancer: A Systematic Review and Meta-Analysis

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Authors

ATAïda Djé Djénèba TraoréASAbibou SimporéAZAbdou Azaque Zouré

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Overview

Systematic review evaluates diagnostic performance of microRNAs miR-21, miR-141, and miR-375 in prostate cancer, indicating their potential over conventional methods.

Key Points

  • MicroRNA miR-21 shows the highest diagnostic accuracy for prostate cancer, with an AUC of 0.92.
  • The combination of miR-21, miR-141, and miR-375 yields an overall diagnostic accuracy of 0.82 for sensitivity.
  • Subgroup analyses indicate whole blood as the most effective sample type, achieving an AUC of 0.91.
  • Standardized prospective studies are necessary for clinical implementation of microRNA diagnostics.

Cite This Study

Traoré et al. (2025) studied this question.

synapsesocial.com/papers/68d475a031b076d99fa6de98https://doi.org/10.9734/arrb/2025/v40i92314
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic accuracy of MicroRNAs as biomarkers for prostate cancer: a systematic review and meta-analysis2026
  2. 2Circulating microRNAs as biomarker in prostate cancer and their significance in the differentiation of benign and malignant conditions of the prostate2025
  3. 3A Brief Review of MicroRNA Profiling in Human Prostate Cancer Tissues and Plasma2025 · 4 citations
  4. 4A panel based on three-miRNAs as diagnostic biomarker for prostate cancer2024 · 5 citations
  5. 5Role and screening potential of let-7b-5p, miR-15a-5p, and miR-15b-5p in human prostate cancer2024