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September 23, 2025Synfacts0 citations

Copper-Catalyzed Enantioconvergent Benzylation of Amides with Alkylboronic Esters

Copper-Catalyzed Enantioconvergent Benzylation of Amides with Alkylboronic Pinacol Esters

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Overview

This method demonstrates efficient amide benzylation and enantioconvergent catalysis, utilizing copper catalysis effectively.

Key Points

  • The reaction achieves high yields of enantioconvergent amides, showcasing copper catalysis's efficiency.
  • Enantioconvergent catalysis successfully produces chiral amides in an efficient manner, utilizing alkylboronic pinacol esters.
  • The Chan–Lam coupling methodology is central to this process, providing a valuable pathway for amide transformation.
  • Significant potential lies in expanding this method for broader applications in synthetic organic chemistry.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68d4764731b076d99fa6dfa7https://doi.org/10.1055/a-2680-9095
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