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February 12, 2026Journal of the American Chemical Society

Copper-Catalyzed Enantioconvergent Radical Deborylative Coupling of Racemic Benzylboronic Esters with Alkynes and Alkenylboronic Esters

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Authors

ZGZeng GaoDXDong-Dong XuLFLiwen Fan

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Overview

This research demonstrates a novel copper-catalyzed method to form chiral C-C bonds, indicating high effectiveness in diverse chemical environments.

Key Points

  • The research aims to develop an efficient copper-catalyzed method for enantioconvergent coupling of alkylboronic esters.
  • Utilized copper with chiral multidentate N,N,P-ligand for catalytic processes.
  • Implemented a radical strategy that enables boron abstraction to generate prochiral radicals.
  • Explored coupling reactions with both alkynes and alkenylboronic esters.
  • Established a new method for C(sp3)-C(sp) coupling of benzylboronic esters.
  • Demonstrated high chemo- and enantioselectivity in the reactions.
  • Showed tolerance to various functional groups and rapid reaction progress with low catalyst loading.

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/698d6d695be6419ac0d5253dhttps://doi.org/10.1021/jacs.5c21668
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