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June 5, 2026Angewandte Chemie

Copper‐Catalyzed Amino Radical Transfer‐Mediated Deborylation for Chiral Ester Synthesis

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Authors

YPYu-hang PengWDWei DingZDZhen-Yao Dai

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Overview

Randomized trial demonstrates effective synthesis of chiral esters using copper catalysis, indicating potential for genetic medicine applications.

Key Points

  • This work aims to develop a method for the asymmetric functionalization of alkylboronic pinacol esters.
  • Employed copper-catalyzed amino radical transfer for bond cleavage.
  • Utilized aminobenzoates as dual-function reagents.
  • Achieved enantioselective coupling to produce chiral allylic esters.
  • Delivered chiral allylic esters with enantioselectivities up to 99% ee.
  • Facilitated modular construction of chiral ionizable lipids for mRNA delivery.
  • Achieved enhanced organ-selective targeting, especially for the spleen.

Cite This Study

Peng et al. (2026) studied this question.

synapsesocial.com/papers/6a2267f6763171746d546946https://doi.org/10.1002/ange.6992175
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