A local Evaluation of Streptokinase Therapy in Acute Myocardial Infarction Patients at TMSS Medical College and Rafatullah Commnuity Hoppital

Introduction: Acute myocardial infarction (AMI) remains a significant public health concern, necessitating prompt diagnosis and treatment. This study aimed to evaluate the clinical characteristics and outcomes of patients with AMI treated with streptokinase therapy at TMSS Medical College & Rafatullah Community Hospital. Objective: To analyze the demographic profile, clinical presentation, and treatment outcomes of patients with AMI undergoing streptokinase therapy. Materials and Methods: A retrospective analysis was conducted on 140 patients admitted to the CCU from January to December 2022. Demographic data, clinical characteristics, and treatment outcomes were collected. Results: The majority of patients were male (72.9%) with an average age of 52.5 years. Common comorbidities included diabetes mellitus (32.9%), hypertension (51.4%), and dyslipidemia (23.6%). Obesity (16.4%) and smoking (52.9%) were prevalent. Delays in hospital admission were observed in 86 patients (61%). Streptokinase therapy was administered to 54 patients, with 40 showing positive responses. Echocardiography revealed a normal LVEF in 52.6% of patients. A negative correlation was found between delayed treatment and LVEF, indicating a poorer prognosis with longer delays. The chi-square test and Cramer's V confirmed a strong association between streptokinase therapy and LVEF. Conclusion: This study highlights the burden of AMI in the study population, emphasizing the importance of timely intervention. Streptokinase therapy demonstrated effectiveness in improving LVEF and reducing mortality. Addressing risk factors such as obesity, smoking, and chronic diseases is crucial for preventing AMI.