Case Report of Primary Hepatoid Lung Carcinoma in a 45-year-old Woman

A 45-year-old woman initially presented with back pain and was subsequently given a diagnosis of hepatoid adenocarcinoma (HAC) of the lung, stage IV, T3N0M1b. No actionable mutations were detected. A multidisciplinary therapeutic approach, including atezolizumab plus bevacizumab treatment, platinum-based doublet chemotherapy, radiotherapy, and surgery, was applied. The patient remained asymptomatic and disease progression free for approximately 34 months after treatment. HAC is a rare lung cancer subtype for which information regarding systemic treatment is limited. The optimal treatment regimen for this cancer requires further investigation.