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February 8, 2026Cancer MedicineOpen Access

A Clinical Guidance for the Management of Patients With Hepatoid Adenocarcinoma and A Case Series

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Authors

CLChristina LiavaSVSudhakar VenkateshMTMichael S. Torbenson

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Overview

This review evaluates management strategies and treatment outcomes in patients with hepatoid adenocarcinoma, indicating a need for improved guidelines.

Key Points

  • The research aims to provide clinical guidance for the management of hepatoid adenocarcinoma (HAC) and explore treatment options.
  • Reviewed clinical features, risk factors, and diagnostic criteria of HAC.
  • Analyzed a cohort of 15 patients diagnosed with HAC from the Mayo Clinic.
  • Discussed emerging therapeutic approaches and prognosis for HAC.
  • TP53 was the most commonly mutated gene (62.5%) among patients.
  • PD-L1 expression was positive in 50% of assessed patients.
  • Only 42.9% of patients received immunotherapy, suggesting limited efficacy data due to small sample size.

Cite This Study

Liava et al. (2026) studied this question.

synapsesocial.com/papers/698828eb0fc35cd7a8848dcbhttps://doi.org/10.1002/cam4.71398
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exceptional Long-Term Survival of a Patient With Hepatoid Adenocarcinoma of the Colon and the Treatment Strategy: A Case Report2024
  2. 2A National Cancer Database analysis of hepatoid adenocarcinoma: Epidemiology, socioeconomic, and clinical factors.2026
  3. 3Giant hepatoid adenocarcinoma of the transverse colon in an 84-year-old woman: A case report and review of the literature2025
  4. 4Case Report of Primary Hepatoid Lung Carcinoma in a 45-year-old Woman2025
  5. 5Preliminary Study of Clinicopathological and Computed Tomography Features of Hepatoid Adenocarcinoma in Stomach2024