Randomized trial shows reduced lesion size and pain in recurrent aphthous stomatitis with alum stone patches, suggesting higher treatment efficacy.
Introduction: This study examined the effects of alum stone administration via adhesive patches on the healing process of recurrent aphthous ulcers. Methods: In this study, 100 females, aged between 22 and 30 years, reported multiple oral aphthous ulcers. The evaluation of recurrent aphthous stomatitis was performed by an oral medicine specialist, who relied on the clinical manifestations of the condition. The experimental group was administered 1 × 1 cm 2 mucosal patches containing 200 mg alum stone, whereas the control group was given placebo patches without any active medication. The size of aphthous lesions and degree of pain were assessed at Days 1, 3, and 5. Statistical analysis was performed with repeated measures ANOVA using R software. Results: The application of alum stone led to a significant reduction in lesion size and pain scores over time in the experimental group, compared to the control group ( P < 0.001). Conclusion: The study’s results indicated that the utilization of alum stone in mucosal adhesive patches yielded significant reductions in the size of aphthous lesions and the degree of pain.
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Hamid et al. (2025) studied this question.
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