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The synthesis improves yield to 47% for primaquine diphosphate in anti-malarial applications, highlighting efficient methods.
An improved three‐step synthesis route toward Primaquine Diphosphate is reported herein. The anti‐malarial drug was obtained via n ‐alkylation of readily available potassium phthalimide, followed by reductive amination and room temperature methylaminolysis‐assisted phthalimido deprotection of the key intermediates to furnish Primaquine Diphosphate in 47% overall isolated yield.
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Akwi et al. (2025) studied this question.
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