In vitro and in silico analyses showed potential anti-inflammatory effects of cogon grass roots extract, suggesting further exploration in alternative treatments.
Key Points
Ethanol extract from cogon grass roots demonstrated anti-inflammatory activity with an IC50 value of 71.79 µg/mL during in vitro analysis.
In silico docking revealed cyclovalone exhibited stronger interactions with COX-1 and COX-2 enzymes compared to the control diclofenac.
The methods employed combined molecular docking techniques along with spectrophotometric assay methods for protein denaturation inhibition.
These results support the potential of cogon grass roots as an alternative anti-inflammatory treatment, warranting further investigation.