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This is a Animal Study study (also classified as: In Vitro Study).

September 26, 2025Open Access

Antidiarrheal activity assessment of Operculina turpethum stem extract and in silico analysis of its compounds

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Ethanolic extract shows significant antidiarrheal effects in mouse model, suggesting possible mechanisms through molecular docking.

The ethanolic extract of O. turpethum displayed significant antidiarrheal activity in the mouse model, indicating potential therapeutic value.
Dose-dependent effects were observed with the extract, particularly at 250 and 500 mg/kg, highlighting its effectiveness.
Molecular docking analysis revealed that three compounds showed strong binding affinity to the M3 muscarinic acetylcholine receptor, comparable to loperamide.
These results support further investigations into the phytochemical and pharmacological properties of O. turpethum stem extracts.

Fahad et al. (2025) studied this question.

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