Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 25, 2025NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCESOpen Access

Isolation and Antidiarrhoeal Activity of Methyl 9, 10-Dimethoxyanthracene-2-Carboxylate from Morinda lucida Stem Bark: A Potential Ethnomedicinal Lead for Diarrhoea Treatment

View Full Paper
Ask AI
Bookmark
Share

Authors

COChukwuebuka Kenechukwu OnyishiHOHannah Ndidiamaka OkorieGUGerald Walter Ugordi

Discussion

Loading...

Member takes

Overview

Isolation shows significant antidiarrhoeal effects in mice, suggesting ethnomedicine potential for Morinda lucida.

Key Points

  • The compound methyl 9,10-dimethoxyanthracene-2-carboxylate significantly reduces gastrointestinal motility.
  • At a dose of 100 mg/kg, it decreased charcoal meal transit to 0.00 cm by 4 hours, outperforming controls.
  • Assessment used a castor oil-induced model in Wistar mice, comparing results to standard antidiarrhoeal agents.
  • Findings support traditional uses of Morinda lucida and emphasize the need for further research on its therapeutic potential.

Cite This Study

Onyishi et al. (2025) studied this question.

synapsesocial.com/papers/68af5f0dad7bf08b1eae1aa9https://doi.org/10.59298/nijrms/2025/6.3.1824
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive Profiling of Antioxidant, Antidiabetic, and Cytotoxic Compounds from Morinda lucida Benth Using 1H-NMR- and UHPLC-Q Exactive Orbitrap MS-Based Metabolomics Combined with Molecular Networking and Molecular Docking2026
  2. 2SOME PHARMACOLOGICAL STUDIES ON MORlNDA LUCIDA1998
  3. 3Anti-Trypanosomal Activities of Methanolic Extracts of Morinda Lucida Fruit, Stem Bark and Root Against Trypanosoma brucei brucei2024
  4. 4Phytochemical profiling and bioactivity validation of Moringa oleifera leaves: Antimicrobial, antidiarrheal, analgesic, and in silico insights.2025 · 7 citations
  5. 5In itro and in silico screening and identification of potential bioactive anthraquinones of Morinda lucida benth against pathogenic bacterial target proteins2024 · 3 citations