SOME PHARMACOLOGICAL STUDIES ON MORlNDA LUCIDA

Objective: The methanol extract (MLE) and fractions (MLFX 2 and MLFX 5 ) isolated from Morinda lucida were studied for some pharmacological properties in animal models. Methods: Carrageenan-induced rat paw oedema model was used to test anti-inflammatory activity; the acetic acid-induced writhings and tail immersion test were used to evaluate analgesic effect; while antipyretic activity was evaluated by inducing pyrexia with lipopolysaccharide, and measuring the rectal temperature. The effect of MLE on phenobarbitone sleeping time was also tested. Results: MLE (6.25-50 mg/kg), and MLFX 2 the carrageenan-induced rat paw oedema. fG and MLFX5 (5 and 10 mg/kg) produced inhibition of LE (50-200 mg/kg) significantly reduced the number of writhings induced by acetic acid and elevated pain threshold in hot water test. MLFX 5 significantly (P<0.05) reduced lipopolysaccharide-induced hyperpyrexia in rats while MLFX2 exhibited no such effects. MLE was also found to potentiate phenobarbitone induced sleeping time. Conclusion: MLE, MLFX2 and MLFX 5 exhibited anti-inflammatory activity; MLE also showed analgesic, antipyretic effects and potentiated phenobarbitone sleeping time. However, MLFX2 showed analgesic activity in the acetic acid test while MLFX5 exihibited antipyretic effect.