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September 10, 2025Journal of Environmental Microbiology and Toxicology

Anti-Trypanosomal Activities of Methanolic Extracts of Morinda Lucida Fruit, Stem Bark and Root Against Trypanosoma brucei brucei

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Authors

SMSadiya Imam MaisulePVP.A. VantsawaGOG.B. Onwumere

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Overview

In vitro test shows M. lucida extracts inhibit T. b. brucei infection in mice, suggesting alternative treatments for trypanosomiasis.

Key Points

  • M. lucida extracts demonstrated significant in vitro anti-trypanosomal activity against T. brucei.
  • The median lethal concentrations (LC50) were 0.463 mg/mL for fruit and 0.406 mg/mL for root extracts.
  • Phytochemical assays indicated the presence of flavonoids and alkaloids, particularly abundant in the root.
  • Extracts from the fruit, stem bark, and root inhibited the infectivity of T. b. brucei, highlighting therapeutic potential.

Cite This Study

Maisule et al. (2024) studied this question.

synapsesocial.com/papers/68c1e07554b1d3bfb60fce12https://doi.org/10.54987/jemat.v12i2.1061
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Also Consider

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  5. 5Qualitative and Quantitative Phytochemical Constituents, Antioxidant Activities, and Antimicrobial Studies of Methanol Extract of Morinda citrifolia Stem2025