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July 26, 2026MetabolitesOpen Access

Comprehensive Profiling of Antioxidant, Antidiabetic, and Cytotoxic Compounds from Morinda lucida Benth Using 1H-NMR- and UHPLC-Q Exactive Orbitrap MS-Based Metabolomics Combined with Molecular Networking and Molecular Docking

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Authors

DTDorcas TlhapiNMNtsoaki Joyce MaleboIMIdah Tichaidza Manduna

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Overview

Randomized trial profiled antioxidant and cytotoxic activities in Morinda lucida, suggesting therapeutic potential.

Key Points

  • This research aims to investigate the phytochemical profiles and pharmacological properties of Morinda lucida.
  • Used 1H-NMR and UHPLC-Q Exactive Orbitrap MS for profiling 77 natural compounds.
  • Conducted in vitro assays for DPPH free radical scavenging, α-glucosidase inhibition, and cytotoxicity.
  • Employed molecular docking to assess interactions between compounds and the α-glucosidase protein.
  • Root extract showed the highest DPPH scavenging activity (IC50 = 7.7550 μg/mL).
  • Stem bark extract exhibited significant α-glucosidase inhibition (IC50 = 79.9 µg/mL).
  • Identified compounds demonstrated notable in silico binding interactions with α-glucosidase.

Cite This Study

Tlhapi et al. (2026) studied this question.

synapsesocial.com/papers/6a65a76fd3aea3239cd783cchttps://doi.org/10.3390/metabo16080523
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antifungal activities of Morinda lucida root extracts against Lasiodiplodia theobromae for post harvest disease management2025
  2. 2Anti-Trypanosomal Activities of Methanolic Extracts of Morinda Lucida Fruit, Stem Bark and Root Against Trypanosoma brucei brucei2024
  3. 3Isolation and Antidiarrhoeal Activity of Methyl 9, 10-Dimethoxyanthracene-2-Carboxylate from Morinda lucida Stem Bark: A Potential Ethnomedicinal Lead for Diarrhoea Treatment2025
  4. 4Phytochemical Analysis, Antioxidant Properties, Anti-nutrient Contents and Antimicrobial Study of Aqueous Extract of Morinda lucinda, Solanum erianthun, and Dryopteris expansa2024
  5. 5In itro and in silico screening and identification of potential bioactive anthraquinones of Morinda lucida benth against pathogenic bacterial target proteins2024 · 3 citations